Author

S. G. Das

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:E. coli· 3 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

J. Krug· 5 shared A. Hagenbeek· 2 shared M. Saebelfeld· 2 shared A. de Visser· 1 shared B. Waclaw· 1 shared J. A. G. de Visser· 1 shared J. Brink· 1 shared M. Mungan· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersEvolutionary Biology

J. Krug

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5 papers

Recent·Most cited

Unpredictable repeatability in molecular evolution

S. G. Das, J. Krug

This study shows that heavy-tailed distributions of beneficial fitness effects lead to unpredictable, repeatable evolution, challenging the standard view of parallel evolution.

bioRxiv · May 24, 2022Evolutionary Biology

A Driven Disordered Systems Approach to Biological Evolution in Changing Environments

S. G. Das, J. Krug, M. Mungan

The paper models antibiotic resistance evolution in bacteria under changing environments using a driven disordered systems framework, revealing hysteresis and memory effects.

bioRxiv · Aug 13, 2021Evolutionary Biology

Antibiotic breakdown by susceptible bacteria enhances the establishment of β-lactam resistant mutants

M. Saebelfeld, S. G. Das, J. Brink, A. Hagenbeek, J. Krug, J. A. G. de Visser

The paper shows that susceptible bacteria breaking down antibiotics can increase the establishment of resistant mutants, despite their low enzymatic activity.

bioRxiv · Apr 20, 2021Evolutionary Biology

Stochastic effects during the establishment of β-lactam resistant E. colimutants indicate conditions for collective resistance

M. Saebelfeld, S. G. Das, A. Hagenbeek, J. Krug, A. de Visser

The paper quantifies single-cell establishment probabilities of β-lactam resistant E. coli mutants under different antibiotic concentrations and environments, revealing stochastic effects and cooperative resistance mechanisms.

bioRxiv · Feb 9, 2021 · PreprintEvolutionary Biology

Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs

S. G. Das, S. O. L. Direito, B. Waclaw, R. J. Allen, J. Krug

The paper develops a mathematical model of fitness landscapes shaped by adaptational tradeoffs, showing predictable properties and accessible evolutionary paths despite ruggedness.

bioRxiv · Jan 15, 2020Evolutionary Biology