J. Krug

Unpredictable repeatability in molecular evolution

This study shows that heavy-tailed distributions of beneficial fitness effects lead to unpredictable, repeatable evolution, challenging the standard view of parallel evolution.

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

The paper shows that small and large bacterial populations adapt to an antibiotic using different mutation types, with small populations favoring high-rate mutations and large populations favoring low-rate, high-benefit mutations.

Conflicting effects of recombination on the evolvability and robustness in neutrally evolving populations

This study investigates how recombination affects evolvability and robustness in neutral evolutionary models, finding non-monotonic relationships and a trade-off between these traits.

A Driven Disordered Systems Approach to Biological Evolution in Changing Environments

The paper models antibiotic resistance evolution in bacteria under changing environments using a driven disordered systems framework, revealing hysteresis and memory effects.

Antibiotic breakdown by susceptible bacteria enhances the establishment of β-lactam resistant mutants

The paper shows that susceptible bacteria breaking down antibiotics can increase the establishment of resistant mutants, despite their low enzymatic activity.

Stochastic effects during the establishment of β-lactam resistant E. colimutants indicate conditions for collective resistance

The paper quantifies single-cell establishment probabilities of β-lactam resistant E. coli mutants under different antibiotic concentrations and environments, revealing stochastic effects and cooperative resistance mechanisms.

The fitness landscapes of translation

The paper examines genetic interactions between synonymous mutations in translation, showing different interaction ranges based on whether translation efficiency is modeled by ribosome current or speed.

Predictable Properties of Fitness Landscapes Induced by Adaptational Tradeoffs

The paper develops a mathematical model of fitness landscapes shaped by adaptational tradeoffs, showing predictable properties and accessible evolutionary paths despite ruggedness.

Recombination and mutational robustness in neutral fitness landscapes

This paper shows that recombination significantly enhances mutational robustness in fitness landscapes, suggesting a link between sexual reproduction and genetic robustness.

Genotypic complexity of Fisher’s geometric model

The paper analyzes Fisher's geometric model to compute the probability of sign epistasis and the complexity of fitness landscapes, showing that phenotypic dimension does not generally correlate with landscape complexity.

Mutation supply and the repeatability of selection for antibiotic resistance

This study investigates how mutation supply and selective pressure affect the repeatability of antibiotic resistance evolution in E. coli using mutant libraries.