P. Ruelens

Density-dependent feedback limits the spread of a beta-lactamase mutant: experimental observations and population dynamic model

The paper investigates how cell density and antibiotic concentration affect the spread of beta-lactamase mutants, showing that density determines whether a resistant strain outcompetes or coexists with a susceptible strain.

Interaction between mutation type and gene pleiotropy drives parallel evolution in the laboratory

The paper investigates how mutation type and gene pleiotropy interact to influence evolutionary repeatability in Escherichia coli, finding that SNPs in highly pleiotropic genes provide greater fitness benefits than indels or structural variants.

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

The paper shows that small and large bacterial populations adapt to an antibiotic using different mutation types, with small populations favoring high-rate mutations and large populations favoring low-rate, high-benefit mutations.

Resurrected protein interaction networks reveal the innovation potential of ancient whole genome duplication

The paper resurrects and compares ancestral protein interaction networks before and after a whole genome duplication in core eudicots, revealing network innovation and modularity maintenance.