G. Mills

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX

This paper determines the structure of Tpp49Aa1 using MHz-SFX and investigates its interaction with Cry48Aa1, expanding its known target range to include additional mosquito species.

In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection

This study identifies a novel host-pathogen interaction where Klebsiella pneumoniae rewires lung macrophages to promote infection by inducing an M(Kp) polarization state.

Direct Observation of the Mechanism of Antibiotic Resistance by Mix-and-Inject at the European XFEL

The paper directly observes fast ligand binding in a biomedically relevant enzyme using MHz X-ray pulses at the European XFEL.

In vitro evolution of colistin resistance in the Klebsiella pneumoniae complex follows multiple evolutionary trajectories with variable effects on fitness and virulence characteristics.

This study shows that Klebsiella pneumoniae complex strains can develop colistin resistance through multiple evolutionary paths, with variable effects on fitness and virulence.

BET inhibition induces an anti-apoptotic adaptive response and therapeutic vulnerability to MCL1 inhibitors in breast cancer

This study shows BET inhibition in breast cancer triggers an anti-apoptotic response via MCL1 upregulation, and co-targeting BET and MCL1 is synergistic and effective in basal-like breast cancers.