A. Durand

Efficient fine-tuning of endothelial gene expression by Y to Phe mutation in the VE-cadherin gene

The paper investigates the effect of a Y685F mutation in VE-cadherin on endothelial gene expression, identifying 884 differentially expressed genes and altered signaling pathways in vivo.

Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task

This study investigates the 5-CSRTT task in rats, finding that response accuracy reflects sustained attention while omissions indicate failure to attend to stimulus location.

Single tyrosine mutation in VE-cadherin modulates gene lung expressions: evidence for FOXF1 mediated S1PR1 upregulation to stabilize vessels in mice

This study shows that a single tyrosine mutation in VE-cadherin increases S1PR1 expression via FOXF1 binding, stabilizing lung vessels in mice.

Biodiversity and distribution of sea anemones (Cnidaria, Anthozoa, Actiniaria) in Peru

This study identifies 23 sea anemone species in Peruvian waters, highlighting regional distribution patterns and habitat preferences, while noting gaps in research.

The Cohesin ATPase cycle is mediated by specific conformational dynamics and interface plasticity of SMC1A and SMC3 ATPase domains

This study characterizes the ATPase cycle of Cohesin by showing how SMC1A and SMC3 domains undergo structural changes, revealing the role of interface plasticity in the cycle.

Luminal progenitors undergo partial epithelial-to-mesenchymal transition at the onset of basal-like breast tumorigenesis

The paper identifies a pre-tumoral state in luminal progenitor cells during basal-like breast tumorigenesis, characterized by partial epithelial-to-mesenchymal transition and epigenomic changes.

The structure of HiSiaQM defines the architecture of tripartite ATP-independent periplasmic (TRAP) transporters

This paper presents the first cryo-EM structure of TRAP transporter membrane domains and identifies structural features that enable monomeric elevator architecture.

H3K27me3 is a determinant of chemotolerance in triple-negative breast cancer

This study identifies H3K27me3 as a key determinant of chemotolerance in triple-negative breast cancer by analyzing single-cell epigenomic and transcriptomic data.

CD44 regulates epigenetic plasticity by mediating iron endocytosis

This study identifies CD44 as a mediator of iron endocytosis linked to epigenetic plasticity, showing iron's role in regulating histone modifications and gene expression during mesenchymal transitions.

A simple microbiome in the European common cuttlefish, Sepia officinalis

This paper characterizes the microbiome of the European common cuttlefish, identifying Vibrionaceae and Piscirickettsiaceae as dominant symbionts in the digestive tract and gills.