Author

A. E. Sheppard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 4 Organism:E. coli· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

N. Stoesser· 4 shared A. S. Walker· 3 shared D. W. Crook· 3 shared A. J. Mathers· 2 shared A. Vaughan· 2 shared H. Parikh· 2 shared J. Swann· 2 shared K. E. Barry· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersMicrobiology

N. Stoesser

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Author profile →

5 papers

Recent·Most cited

Discordance between different bioinformatic methods for identifying resistance genes from short-read genomic data, with a focus on Escherichia coli

T. J. Davies, J. Swann, A. E. Sheppard, H. Pickford, S. Lipworth, M. AbuOun, M. Ellington, P. W. Fowler, S. Hopkins, K. Hopkins, D. Crook, T. E. Peto, M. F. Anjum, A. S. Walker, N. Stoesser

This study evaluates four AMR gene typing methods using simulated and real E. coli data, revealing significant discrepancies and highlighting issues with current bioinformatic approaches.

bioRxiv · Nov 3, 2021 · PreprintMicrobiology

Reconciling the potentially irreconcilable? Genotypic and phenotypic amoxicillin-clavulanate resistance in Escherichia coli

T. J. Davies, N. Stoesser, A. E. Sheppard, M. Abuoun, P. W. Fowler, J. Swann, P. Quan, D. Griffiths, A. Vaughan, M. Morgan, H. T. T. Phan, K. J. Jeffery, M. Andersson, M. Ellington, O. Ekelund, , A. S. Walker

This study shows that amoxicillin-clavulanate resistance in E. coli is quantitative, not binary, and that WGS-based predictions outperform traditional phenotyping methods.

bioRxiv · Feb 6, 2020Microbiology

Genomic analysis of carbapenemase-encoding plasmids from Klebsiella pneumoniae across Europe highlights three major patterns of dissemination

S. David, V. Cohen, S. Reuter, A. E. Sheppard, T. Giani, J. Parkhill, the European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group, the ESCMID Study Group for Epidemiological Markers (ESGEM), G. M. Rossolini, E. J. Feil, H. Grundmann, D. M. Aanensen

This study analyzes carbapenemase-encoding plasmids in K. pneumoniae across Europe using long-read sequencing, identifying three distinct dissemination patterns of resistance genes.

bioRxiv · Dec 19, 2019 · PreprintMicrobiology

The Role of fosA in Challenges with Fosfomycin Susceptibility Testing of Multispecies Klebsiella pneumoniae Carbapenemase-Producing Clinical Isolates

Z. S. Elliott, K. E. Barry, H. L. Cox, N. Stoesser, J. Carroll, K. B. Vegesana, S. M. Kotay, A. E. Sheppard, A. M. Wailan, D. W. Crook, H. Parikh, A. J. Mathers

This study evaluates fosfomycin susceptibility testing in KPC-producing Klebsiella pneumoniae isolates and finds that fosA gene presence affects test accuracy, with sodium phosphonoformate improving results.

bioRxiv · Apr 18, 2019Microbiology

Klebsiella quasipneumonaiae provides a window into carbapenemase gene transfer, plasmid rearrangements and nosocomial acquisition from the hospital environment

A. J. Mathers, D. W. Crook, A. Vaughan, K. E. Barry, K. Vegesana, N. Stoesser, H. Parikh, R. Sebra, S. M. Kotay, A. S. Walker, A. E. Sheppard

The paper tracks K. quasipneumoniae's acquisition of carbapenemase plasmids and environmental persistence in a hospital setting over multiple years.

bioRxiv · Dec 4, 2018 · PreprintMicrobiology