Author

A. El-Sagheer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:DNA methylation· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

T. Brown· 4 shared A. Kanaras· 2 shared K. Alexaki· 2 shared R. O. C. Oreffo· 2 shared S. Lanham· 2 shared A. Mazumder· 1 shared A. N. Kapanidis· 1 shared A. Shivalingam· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCell Biology

T. Brown

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Author profile →

4 papers

Recent·Most cited

Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

R. Andrews, H. Steuer, A. El-Sagheer, A. Mazumder, H. el Sayyed, A. Shivalingam, T. Brown, A. N. Kapanidis

The paper introduces Gap-Seq, a single-molecule imaging method that links DNA sequence to protein-DNA interaction kinetics by analyzing transient DNA binding to gapped substrates.

bioRxiv · Feb 27, 2022 · PreprintBiophysics

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles

E. Matthews, S. Lanham, K. White, M.-E. Kyriazi, K. Alexaki, A. El-Sagheer, T. Brown, A. Kanaras, J. West, B. D. MacArthur, P. S. Stumpf, R. O. C. Oreffo

The paper uses single-cell RNA sequencing to identify new targets for isolating skeletal stem cells from human bone marrow using DNA-coated gold nanoparticles.

bioRxiv · Jun 17, 2020 · PreprintCell Biology

Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids

M. Xavier, M. Kyriazi, S. Lanham, K. Alexaki, A. El-Sagheer, T. Brown, A. Kanaras, R. O. C. Oreffo

This paper isolates and enriches skeletal stem cells (SSCs) from human bone marrow using DNA-gold nanoparticles targeting specific mRNA signatures.

bioRxiv · Dec 19, 2019 · PreprintCell Biology

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

F. Paoletti, A. El-Sagheer, J. Allard, T. Brown, O. Dushek, F. Esashi

This study shows RAD51 binds faster to flexible single-stranded DNA than rigid DNA or double-stranded DNA, suggesting DNA flexibility aids in homologous recombination.

bioRxiv · Jun 25, 2019Biochemistry