T. Brown

Avoidable false PSMC population size peaks occur across numerous studies

The paper identifies and resolves false population size peaks in PSMC analyses, showing they result from parameter settings and not true population dynamics.

Resilience in a time of stress: revealing the molecular underpinnings of coral survival following thermal bleaching events

This study identifies molecular biomarkers of coral resilience to thermal bleaching by comparing proteomic, microbiome, and physiological traits of surviving and dying corals.

Anatomically-specific coupling between innate immune gene repertoire and microbiome structure during coral evolution.

The paper examines the relationship between coral innate immune gene copy numbers and microbiome structure across different anatomical sites, finding anatomically specific correlations.

Evidence for microbially-mediated tradeoffs between growth and defense throughout coral evolution

This study shows that microbial symbionts, particularly Endozoicomonas, influence coral growth and disease susceptibility across 425 million years of evolution.

Expanded olfactory system in fishes capable of terrestrial exploration

The paper examines the relationship between ecological traits and olfactory receptor gene expansions in ray-finned fishes, finding convergent increases in olfactory system size in amphibious species.

Disease-associated mutations in WDR34 lead to diverse impacts on the assembly and function of dynein-2.

The study examines how disease-associated WDR34 mutations affect cilia assembly and function in a knockout cell model, revealing diverse phenotypic impacts.

Transient DNA binding to gapped DNA substrates links DNA sequence to the single-molecule kinetics of protein-DNA interactions

The paper introduces Gap-Seq, a single-molecule imaging method that links DNA sequence to protein-DNA interaction kinetics by analyzing transient DNA binding to gapped substrates.

Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding

This study identifies gene losses in vampire bats linked to adaptations for blood feeding, including metabolic, physiological, and sensory changes.

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles

The paper uses single-cell RNA sequencing to identify new targets for isolating skeletal stem cells from human bone marrow using DNA-coated gold nanoparticles.

Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids

This paper isolates and enriches skeletal stem cells (SSCs) from human bone marrow using DNA-gold nanoparticles targeting specific mRNA signatures.

Molecular flexibility of DNA as a key determinant of RAD51 recruitment

This study shows RAD51 binds faster to flexible single-stranded DNA than rigid DNA or double-stranded DNA, suggesting DNA flexibility aids in homologous recombination.