Author

R. O. C. Oreffo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5 Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 7 Organism:mouse· 4 Organism:human· 3 Research Focus:development & morphogenesis· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1

Frequent Co-Authors

J. M. Kanczler· 5 shared C. Echalier· 4 shared J. I. Dawson· 4 shared J. P. Wojciechowski· 4 shared K. M. Marshall· 4 shared M. M. Stevens· 4 shared S. J. P. Callens· 3 shared S. Lanham· 3 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersBioengineering

J. M. Kanczler

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Author profile →

8 papers

Recent·Most cited

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite(R) to deliver BMP-2 in an ovine femoral condyle defect model

K. M. Marshall, J. S. McLaren, J. P. Wojciechowski, S. J. P. Callens, C. Echalier, J. M. Kanczler, F. R. A. J. Rose, M. M. Stevens, J. I. Dawson, R. O. C. Oreffo

This study evaluates Laponite(R)-coated scaffolds for delivering BMP-2 in a large animal bone defect model, showing enhanced bone formation compared to uncoated scaffolds.

bioRxiv · Feb 25, 2024Bioengineering

Bioactive coatings on 3D printed polycaprolactone scaffolds for bone regeneration: a novel murine femur defect model for examination of the biomaterial capacity for repair.

K. M. Marshall, J. P. Wojciechowski, V. Jayawarna, A. Hasan, C. Echalier, S. J. P. Callens, T. Yang, J. M. Kanczler, J. I. Dawson, A. Mata, M. Salmeron-Sanchez, M. M. Stevens, R. O. C. Oreffo

This study evaluates bioactive coatings on 3D printed PCL-TMA900 scaffolds for bone regeneration using a murine femur defect model, finding that Laponite/BMP-2 coating significantly promotes bone formation without heterotopic bone formation.

bioRxiv · Dec 15, 2023Bioengineering

Bioactive coatings on 3D printed scaffolds for bone regeneration: Use of Laponite™ to deliver BMP-2 for bone tissue engineering - progression through in vitro, chorioallantoic membrane assay and murine subcutaneous model validation.

K. M. Marshall, J. P. Wojciechowski, C. Echalier, S. J. P. Callens, T. Yang, O. Ovrebo, V. Jayawarna, J. M. Kanczler, M. M. Stevens, J. I. Dawson, R. O. C. Oreffo

This paper evaluates Laponite-coated scaffolds for delivering BMP-2 to enhance bone regeneration, showing effective osteoinduction in vitro and in vivo with delayed use.

bioRxiv · Oct 25, 2023Bioengineering

Bioactive coatings on 3D printed scaffolds for bone regeneration: Translation from in vitro to in vivo models and the impact of material properties and growth factor concentration.

K. M. Marshall, J. P. Wojciechowski, V. Jayawarna, A. Hasan, C. Echalier, O. Ovrebo, T. Yang, J. M. Kanczler, A. Mata, M. Salmeron-Sanchez, M. M. Stevens, R. O. C. Oreffo

This study evaluates bioactive coatings on 3D-printed PCL-TMA scaffolds for bone regeneration, showing in vitro osteogenic response but no significant in vivo bone formation.

bioRxiv · Oct 22, 2023Bioengineering

Biofabrication of nanocomposite-based scaffolds containing human bone extracellular matrix for the differentiation of skeletal stem and progenitor cells

Y.-H. Kim, J. M. Kanczler, S. Lanham, A. Rawlings, M. Roldo, G. Tozzi, J. I. Dawson, G. Cidonio, R. O. C. Oreffo

This paper develops a nanocomposite bioink using human bone extracellular matrix, nanoclay, and alginate for 3D bioprinting to support osteogenic differentiation of bone marrow stromal cells in vitro and ex vivo.

bioRxiv · Apr 7, 2023 · PreprintBioengineering

Single cell RNA sequence analysis of human bone marrow samples reveals new targets for isolation of skeletal stem cells using DNA-coated gold nanoparticles

E. Matthews, S. Lanham, K. White, M.-E. Kyriazi, K. Alexaki, A. El-Sagheer, T. Brown, A. Kanaras, J. West, B. D. MacArthur, P. S. Stumpf, R. O. C. Oreffo

The paper uses single-cell RNA sequencing to identify new targets for isolating skeletal stem cells from human bone marrow using DNA-coated gold nanoparticles.

bioRxiv · Jun 17, 2020 · PreprintCell Biology

Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptors

E. Neto, L. Leitao, J. Mateus, D. Sousa, F. Conceicao, C. J. Alves, R. O. C. Oreffo, J. West, P. Aguiar, M. Lamghari

This study shows that osteoclast-derived extracellular vesicles promote sensory neuron sprouting and electrophysiology via EGFR activation.

bioRxiv · Apr 4, 2020 · PreprintCell Biology

Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids

M. Xavier, M. Kyriazi, S. Lanham, K. Alexaki, A. El-Sagheer, T. Brown, A. Kanaras, R. O. C. Oreffo

This paper isolates and enriches skeletal stem cells (SSCs) from human bone marrow using DNA-gold nanoparticles targeting specific mRNA signatures.

bioRxiv · Dec 19, 2019 · PreprintCell Biology