A. Federico

A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes

This paper develops a network-based toxicology approach to model nanomaterial hazard by linking molecular changes to adverse outcomes in biological systems.

Toxicogenomic Assessment of In Vitro Macrophages Exposed to Profibrotic Challenge.

This study uses RNA sequencing to analyze immune gene responses in macrophages exposed to bleomycin, identifying dose-dependent gene alterations and linking them to cytokine and proteinase activity.

Beyond Basic Characterization and Omics: Immunomodulatory Roles of Platelet-Derived Extracellular Vesicles Unveiled by Functional Testing

This study investigates the immunomodulatory roles of platelet-derived extracellular vesicles by comparing their functional effects and omics profiles across different activation methods.

Molecular annotation of AOPs guides the development of the next generation mechanistic chemical safety assessment and new approach methods

This paper develops a framework to annotate Adverse Outcome Pathways (AOPs) using molecular data, enabling better integration of toxicogenomics into chemical safety assessment.

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

The paper identifies two compounds that inhibit SARS-CoV-2 infection and syncytia formation through computational prioritization and in vitro testing.

animalcules: Interactive Microbiome Analytics 1 and Visualization in R

animalcules provides an interactive R toolkit for analyzing 16S rRNA, shotgun metagenomics, and metatranscriptomics data with visualization and machine learning tools.

Yap suppresses T cell function and infiltration in the tumor microenvironment

This study shows that Yap inhibits T cell function and infiltration in tumors, and its inhibition enhances anti-tumor immunity.