S. Monti

Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes

This study shows insulin-resistant adipocyte exosomes promote TNBC aggressiveness and brain metastasis via miRNA pathways.

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity

The paper analyzes immune cell changes in centenarians and younger individuals to identify aging and longevity signatures in peripheral blood cells.

Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease

This study identifies plasma exosomal miRNAs associated with T2D that induce EMT and immune checkpoint expression in prostate cancer cells.

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens

The paper develops a classification system to identify PPARγ ligands and categorize chemicals as white or brite adipogens using RNA-Seq and lipid accumulation data.

animalcules: Interactive Microbiome Analytics 1 and Visualization in R

animalcules provides an interactive R toolkit for analyzing 16S rRNA, shotgun metagenomics, and metatranscriptomics data with visualization and machine learning tools.

Yap suppresses T cell function and infiltration in the tumor microenvironment

This study shows that Yap inhibits T cell function and infiltration in tumors, and its inhibition enhances anti-tumor immunity.

Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models

This study shows that tributyltin, an environmental PPARγ ligand, induces adipogenesis but lacks the ability to promote mitochondrial biogenesis or brite adipocyte features compared to rosiglitazone.