A. Serra

A network toxicology approach for mechanistic modelling of nanomaterial hazard and adverse outcomes

This paper develops a network-based toxicology approach to model nanomaterial hazard by linking molecular changes to adverse outcomes in biological systems.

Toxicogenomic Assessment of In Vitro Macrophages Exposed to Profibrotic Challenge.

This study uses RNA sequencing to analyze immune gene responses in macrophages exposed to bleomycin, identifying dose-dependent gene alterations and linking them to cytokine and proteinase activity.

Substrate-binding Glycine Residues are Major Determinants for Hydrolase and Ligase Activity of Plant Legumains

The paper identifies conserved glycine residues as key determinants distinguishing peptide asparaginyl ligases (PALs) from asparaginyl endopeptidases (AEPs) in plant legumains.

Molecular annotation of AOPs guides the development of the next generation mechanistic chemical safety assessment and new approach methods

This paper develops a framework to annotate Adverse Outcome Pathways (AOPs) using molecular data, enabling better integration of toxicogenomics into chemical safety assessment.

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation

The paper identifies two compounds that inhibit SARS-CoV-2 infection and syncytia formation through computational prioritization and in vitro testing.