Author

B. D. Cosgrove

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Cancer Biology· 3 Bioengineering· 1

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Research Focus:cell type annotation· 7 Organism:mouse· 5 Approach:deep learning· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. J. De Micheli· 5 shared A. Flesken-Nikitin· 3 shared A. Y. Nikitin· 2 shared D.-J. Fu· 2 shared O. Elemento· 2 shared P. Fraczek· 2 shared A. E. Thalacker-Mercer· 1 shared A. M. Loiben· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersCell Biology

A. J. De Micheli

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Author profile →

8 papers

Recent·Most cited

Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis

A. Flesken-Nikitin, M. G. Pirtz, C. S. Ashe, L. H. Ellenson, B. D. Cosgrove, A. Y. Nikitin

This study identifies 44 genes, including novel markers like OAS2 and OASL, as potential early diagnostic and prognostic markers for serous endometrial carcinoma using a mouse model and multi-omics approaches.

bioRxiv · Mar 15, 2024 · PreprintCancer Biology

Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma

A. Flesken-Nikitin, C. Q. Ralston, D.-J. Fu, A. J. De Micheli, D. J. Phuong, B. A. Harlan, A. P. Armstrong, D. McKellar, S. Ghuwalewala, J. C. Schimenti, B. D. Cosgrove, A. Y. Nikitin

The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.

bioRxiv · Dec 12, 2023Cancer Biology

PAX8 expressing epithelial cells are a cancer-prone source of clonal cyclical regeneration of endometrial epithelium

D.-J. Fu, A. J. De Micheli, M. Bidarimath, L. Ellenson, B. D. Cosgrove, A. Flesken-Nikitin, A. Nikitin

The paper was withdrawn due to authorship issues and should not be cited.

bioRxiv · Jun 7, 2023Cancer Biology

Long-term high-yield skeletal muscle stem cell expansion through staged perturbation of cytokine signaling in a soft hydrogel culture platform

A. M. Loiben, K. H. Kim, S. Y. Soueid-Baumgarten, V. M. Aguilar, J. Chin Cheong, R. F. Kopyto, P. Fraczek, E. H. H. Fong, R. Mangal, L. A. Archer, B. D. Cosgrove

This paper develops a method to expand skeletal muscle stem cells long-term using a hydrogel substrate, cytokine cocktail, and staged p38/{beta} inhibition, achieving high yields of functional Pax7+ cells.

bioRxiv · Jun 4, 2020 · PreprintBioengineering

Single-cell Transcriptomics Identify Extensive Heterogeneity in the Cellular Composition of Mouse Achilles Tendons

A. J. De Micheli, J. B. Swanson, N. P. Disser, L. M. Martinez, N. R. Walker, D. J. Oliver, B. D. Cosgrove, C. L. Mendias

The paper uses single-cell RNA sequencing to identify 11 cell types in mouse Achilles tendons, including three new fibroblast populations, and models cell interactions.

bioRxiv · Apr 2, 2020Cell Biology

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations

A. J. De Micheli, J. A. Spector, O. Elemento, B. D. Cosgrove

This study creates a single-cell transcriptomic atlas of human skeletal muscle, identifying two distinct muscle stem cell subpopulations with different transcriptional profiles and disease associations.

bioRxiv · Jan 21, 2020Cell Biology

Serine and glycine are essential for human muscle progenitor cell population expansion

B. J. Gheller, J. E. Blum, E. L. Bender, M. E. Gheller, E. W. Lim, M. K. Handzlik, P. J. Stover, M. S. Field, B. D. Cosgrove, C. M. Metallo, A. E. Thalacker-Mercer

This study identifies serine and glycine as essential for human muscle progenitor cell proliferation and shows their availability declines with age, impairing muscle regeneration.

bioRxiv · Nov 7, 2019 · PreprintCell Biology

Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration

A. J. De Micheli, P. Fraczek, S. Soueid-Baumgarten, H. Ravichandran, I. De Vlaminck, O. Elemento, B. D. Cosgrove

This study uses scRNA-seq to map muscle stem cell hierarchy and identifies heterotypic communication signals during skeletal muscle regeneration.

bioRxiv · Jun 17, 2019Cell Biology