A. R. Anderson

Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.

Engineering the microstructure and spatial bioactivity of MAP scaffolds in vitro instructs neovascularization in vivo

This study tunes microstructure and bioactivity of MAP scaffolds to guide cell patterning and promote vessel formation in vitro and enhance neovascularization in vivo.

Gattaca: Base pair resolution mutation tracking for somatic evolution studies using agent-based models

Gattaca generates base-pair resolution artificial genomes to track somatic mutations in agent-based models, enabling in-silico studies comparable to human somatic evolution.

High school Internship Program in Integrated Mathematical Oncology (HIP IMO) - five-year experience at Moffitt Cancer Center

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype

The paper investigates how harsh microenvironments in early breast cancer select for a Warburg phenotype through metabolic and transcriptomic changes.

Click by Click Microporous Annealed Particle (MAP) Scaffolds

This paper develops a tunable MAP scaffold using click chemistry to adjust hydrogel rigidity and demonstrates its biocompatibility in an ischemic stroke model.

Towards multi-drug adaptive therapy

This paper introduces three novel concepts to aid in designing multi-drug adaptive therapies for cancer by analyzing tumor evolution dynamics and treatment strategies.

Tissue structure accelerates evolution: premalignant sweeps precede neutral expansion

This study shows that tissue structure influences tumor evolution by accelerating neutral expansion through spatial constraints and dispersal events.

Macrophage-mediated immunoediting drives ductal carcinoma evolution: Space is the game changer

This study uses immunohistochemistry data to model how macrophages influence tumor evolution through spatial dynamics and immune escape strategies in ductal carcinomas.

The Goldilocks Window of Personalized Chemotherapy: An Immune Perspective

This study uses mathematical modeling to show that optimal chemotherapy scheduling must balance tumor reduction and immune preservation to maximize treatment efficacy.

Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model

This study uses computational modeling to infer tumour proliferative hierarchy by analyzing phylogenetic tree measures under cancer stem cell and neutral evolution assumptions.