Author

A. Dhawan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Organism:rat· 2

Frequent Co-Authors

A. Durmaz· 2 shared J. G. Scott· 2 shared J. Lathia· 2 shared L. N. Paschall· 2 shared M. Hitomi· 2 shared S. Szczesny· 2 shared A. A. Osman· 1 shared A. C. Tan· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersEvolutionary Biology

A. Durmaz

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Author profile →

9 papers

Recent·Most cited

Homologous recombination promotes mitotic death to suppress the innate immune response

R. Szmyd, S. Casolin, L. French, A. Gonzalez Manjon, A. Dhawan, C. B. Nelson, L. Cavalli, S. G. Page, E. Hau, H. A. Pickett, H. E. Gee, A. J. Cesare

The paper shows that homologous recombination (HR) promotes mitotic death, which suppresses the innate immune response by preventing immunogenic cell death.

bioRxiv · May 4, 2024 · PreprintCell Biology

Allograft and Autograft Anterior Cruciate Ligament Reconstructions Exhibit a Similar Biological Response to Cyclic Loading

L. N. Paschall, A. Tsai, E. Tabdanov, A. Dhawan, S. Szczesny

This study compares the biological response of allograft and autograft ACL reconstructions to cyclic loading and finds no difference in remodeling or immune cell markers.

bioRxiv · Mar 20, 2024Bioengineering

miR-644a is a tumor cell-intrinsic mediator of sex bias in glioblastoma

E. S. Hong, S. Z. Wang, A. K. Ponti, N. Hajdari, J. Lee, E. E. Mulkearns-Hubert, J. Volovetz, K. E. Kay, J. Lathia, A. Dhawan

This study identifies miR-644a as a tumor cell-intrinsic mediator of sex bias in glioblastoma, showing it is more highly expressed in females and its target genes are linked to poorer survival.

bioRxiv · Mar 11, 2024Cancer Biology

Cyclic Loading Induces Anabolic and Catabolic Gene Expression in ACLs in a Load-Dependent and Sex-Specific Manner

L. N. Paschall, S. Carrozzi, E. D. Tabdanov, A. Dhawan, S. Szczesny

This study shows cyclic loading induces sex-specific anabolic and catabolic gene expression in ACLs, with male ACLs responding to lower loads and female ACLs downregulating remodeling genes across all loads.

bioRxiv · Nov 11, 2022Bioengineering

FAK drives resistance to therapy in HPV-negative head and neck cancer in a p53-dependent manner.

P. M. Pifer, L. Yang, M. Kumar, T. Xie, M. Frederick, A. Hefner, B. Beadle, D. Molkentine, J. Molkentine, A. Dhawan, M. Abdelhakiem, A. A. Osman, J. N. Myers, C. R. Pickering, V. C. Sandulache, , H. D. Skinner

This study identifies FAK as a driver of therapy resistance in HPV-negative HNSCC, showing its role is dependent on mutant TP53.

bioRxiv · Jun 3, 2022Cancer Biology

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

G. Assante, S. Chandrasekaran, S. Ng, A. Tourna, C. H. Chung, K. A. Isse, C. Filippi, A. Dhawan, M. Liu, S. G. Rozen, M. Hoare, P. Campbell, J. W. O. Ballard, N. Turner, M. J. Morris, , N. A. Youngson

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

bioRxiv · Jul 22, 2021Cancer Biology

Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewings sarcoma

J. A. Scarborough, E. McClure, P. Anderson, A. Dhawan, A. Durmaz, S. L. Lessnick, M. Hitomi, J. G. Scott

This study maps the temporal evolution of collateral sensitivity and resistance in Ewings sarcoma, showing unpredictable patterns in drug response and highlighting transcriptomic changes associated with these states.

bioRxiv · Feb 11, 2020Evolutionary Biology

Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

R. Vander Velde, N. Yoon, V. Marusyk, A. Durmaz, A. Dhawan, D. Myroshnychenko, D. Peral, B. Desai, O. Balynska, J. Poleszhuk, K. Liu, M. Abazeed, A. C. Tan, O. Mian, E. Haura, , A. Marusyk

The paper investigates resistance to ALK inhibitors in NSCLC, finding that resistance develops through gradual, multifactorial genetic and epigenetic changes rather than single mutations or reprogramming.

bioRxiv · Nov 19, 2019Cancer Biology

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces

J. G. Scott, A. Dhawan, A. Hjelmeland, J. Lathia, A. Chumakova, M. Hitomi, A. G. Fletcher, P. K. Maini, A. R. A. Anderson

The paper unifies the cancer stem cell and stochastic models using a continuum model of microenvironmental forces, supported by clonogenic assay results.

Current Stem Cell Reports · Feb 15, 2019Peer-reviewedCancer Biology