Author

A. Hjelmeland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

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Research Focus:cancer & tumor microenvironment· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

D. Parker· 2 shared K. Mitra· 2 shared A. Burlingame· 1 shared A. Chumakova· 1 shared A. Dhawan· 1 shared A. G. Fletcher· 1 shared A. Gunter· 1 shared A. Moran· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

D. Parker

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Author profile →

5 papers

Recent·Most cited

PKD-1 Signaling Is Required for the Maintenance of CSCs with Epithelial-mesenchymal Plasticity in Pancreatic Neuroendocrine Tumors

Y. Guo, Y. Jiang, J. B. Rose, R. Jaskula-Sztul, A. Hjelmeland, H. Chen, B. Ren

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

bioRxiv · Feb 17, 2022 · PreprintCancer Biology

Fine-tuned repression of Drp1 driven mitochondrial fission primes a slow cycling stem/progenitor-like state towards accelerating neoplastic transformation of keratinocytes

K. Mitra, B. M. Spurlock, D. Parker, M. Basu, A. Hjelmeland, S. Gc, S. Liu, G. P. Siegal, A. Gunter, A. Moran

The paper shows that fine-tuned Drp1 repression primes keratinocytes for neoplastic transformation by maintaining a stem/progenitor-like state with elevated stem markers and Cyclin E.

bioRxiv · Mar 5, 2021Cell Biology

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

S. Bastola, M. S. Pavlyukov, Y. Ghochani, N. Sharma, M. A. Nakano, D. Muthukrishnan, S. Y. Yu, M. S. Kim, A. Sohrabi, N. P. Biscola, D. Yamashita, K. Anufrieva, R. Kawaguchi, Y. Qin, S. K. Seidlits, , H. Kornblum

This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.

bioRxiv · Oct 12, 2020 · PreprintCancer Biology

Recasting the cancer stem cell hypothesis: unification using a continuum model of microenvironmental forces

J. G. Scott, A. Dhawan, A. Hjelmeland, J. Lathia, A. Chumakova, M. Hitomi, A. G. Fletcher, P. K. Maini, A. R. A. Anderson

The paper unifies the cancer stem cell and stochastic models using a continuum model of microenvironmental forces, supported by clonogenic assay results.

Current Stem Cell Reports · Feb 15, 2019Peer-reviewedCancer Biology

Mito-SinCe2 Approach to Quantify Relationships between Mitochondrial Dynamics and Energetics status

K. Mitra, B. Spurlock, P. Gupta, M. K. Basu, A. Mukherjee, A. Hjelmeland, V. Darley-Usmar, D. Parker, M. Foxall

The paper develops and validates mito-SinCe2, an approach to quantify the relationship between mitochondrial dynamics and energetics, revealing distinct states and linear relationships in ovarian tumor initiating cells.

bioRxiv · Feb 1, 2019 · PreprintCell Biology