Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain
A. U. Quadros, A. G. d. M. Maganin, E. A. Silva, S. Damasceno, M. C. M. Cavallini, M. Davoli-Ferreira, A. H. Lopes, D. R. Sagar, L. Brandolini, S. H. Lee, J. C. Alves-Filho, F. Cunha, T. Berta, J. Koehl, M. Alegretti, , T. M. Cunha
This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.
bioRxiv · Jul 1, 2022 · PreprintPharmacology & Toxicology