F. Cunha

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

Pyronaridine Protects Against SARS-CoV-2 in Mouse

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

This study links RA to oral microbial dysbiosis and worsened periodontal conditions through analysis of subgingival microbiota and inflammatory markers.