S. Damasceno

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

Sensory neuron-associated macrophages proliferate in the sensory ganglia after peripheral nerve injury in a CX3CR1 signaling dependent manner

This study shows that sensory neuron-associated macrophages proliferate in the sensory ganglia after nerve injury, driven by CX3CR1 signaling, and contribute to inflammation.

Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

Pyronaridine Protects Against SARS-CoV-2 in Mouse

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.