T. M. Cunha

Targeting C5aR1 signaling reduced neutrophil extracellular traps and ameliorates COVID-19 pathology

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

Targeting Neutrophils Extracellular Traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

This study shows that DNase I treatment reduces NETs and organ injury in a COVID-19 mouse model.

Sensory neuron-associated macrophages proliferate in the sensory ganglia after peripheral nerve injury in a CX3CR1 signaling dependent manner

This study shows that sensory neuron-associated macrophages proliferate in the sensory ganglia after nerve injury, driven by CX3CR1 signaling, and contribute to inflammation.

SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster Astrocytes

This study shows SARS-CoV-2 infection alters carbon metabolism in hamster astrocytes, with glutamine dependency for replication and links to neurological symptoms.

Pyronaridine Protects Against SARS-CoV-2 in Mouse

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

Infection of human lymphomononuclear cells by SARS-CoV-2

This study investigates SARS-CoV-2 infection of human lymphomononuclear cells in vitro and in vivo, finding that monocytes, B cells, and T cells are susceptible to infection and viral replication.