J. C. Alves-Filho

This study shows that T cell-specific P2RX7 promotes lung CD4+ T cell accumulation and pathology during severe lung infections like TB and influenza.

This study shows that inhibiting C5aR1 signaling reduces neutrophil extracellular traps and improves lung pathology in COVID-19.

This study identifies C5aR1 signaling in sensory neuron-associated macrophages as a driver of neuropathic pain and shows it can be inhibited to reduce pain.

This study shows that sensory neuron-associated macrophages proliferate in the sensory ganglia after nerve injury, driven by CX3CR1 signaling, and contribute to inflammation.

This study shows that IL-33 plays an age-dependent role in post-sepsis immunosuppression, with adults showing increased IL-33 and Tregs while infants are resistant to secondary infections.

This study tests FDA-approved kinase inhibitors against SARS-CoV-2 in vitro and in vivo, finding that vandetanib reduces inflammatory cytokines and mitigates lung inflammation in infected mice without reducing viral load.

Pyronaridine reduces SARS-CoV-2 viral load and lung pathology in mice, with in vitro inhibition of viral PLpro and host kinase CAMK1.

This study investigates SARS-CoV-2 infection of human lymphomononuclear cells in vitro and in vivo, finding that monocytes, B cells, and T cells are susceptible to infection and viral replication.