Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
Z. Shan, A. Rivero-Gamez, D. Lyumkis, N. C. Horton
The paper presents two cryo-EM structures of filamentous SgrAI to elucidate the two-metal ion mechanism of DNA cleavage during enzymatic activity.
bioRxiv · May 1, 2024Biochemistry
T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis
This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.
bioRxiv · Jan 26, 2024 · PreprintBiochemistry
Y. Chen, R. Yang, B. Qi, Z. Shan
This study identifies Chi3l1 as a host protein that interacts with bacterial peptidoglycan in the gut mucus to regulate microbiota composition and prevent colitis.
bioRxiv · Oct 3, 2023Microbiology
S. Aiyer, P. R. Baldwin, S. M. Tan, Z. Shan, J. Oh, A. Mehrani, M. E. Bowman, G. Louie, D. O. Passos, S. Đorđevic-Marquardt, M. Mietzsch, J. A. Hull, S. Hoshika, B. A. Barad, D. Grotjahn, , D. Lyumkis
This study improves cryo-EM data collection by reducing resolution attenuation during stage tilt, enabling isotropic map reconstruction of specimens with preferred orientations.
bioRxiv · Jul 14, 2023Biophysics
M. Li, D. Passos, Z. Shan, S. J. Smith, Q. Sun, A. Biswas, I. Choudhuri, T. Strutzenberg, A. Haldane, N. Deng, Z. Li, X.-Z. Zhao, T. R. Burke, R. M. Levy, S. H. Hughes, , D. Lyumkis
The paper investigates mechanisms of HIV-1 integrase resistance to Dolutegravir and shows that 4d is more effective against resistant variants.
bioRxiv · Dec 4, 2022Biophysics
A. Ballandras-Colas, V. Chivukula, D. T. Gruszka, Z. Shan, P. K. Singh, V. E. Pye, R. K. McLean, G. J. Bedwell, W. Li, A. Nans, N. J. Cook, H. J. Fadel, E. M. Poeschla, D. J. Griffiths, J. Vargas, , P. Cherepanov
This study reports cryo-EM structures of the lentiviral intasome and shows that multivalent interactions are essential for integrase function and virus infectivity.
bioRxiv · Jan 26, 2022Biochemistry
Z. Shan, L. Li, C. L. Atkins, M. Wang, Y. Wen, J. Jeong, N. Moreno, D. Feng, X. Gui, N. Zhang, C. G. Lee, J. A. Elias, W. Lee, B. Gao, F. W. Lam, , C. Ju
This study identifies Chi3l1 as a key mediator of acetaminophen-induced liver injury by promoting hepatic platelet recruitment through the CD44 axis.
bioRxiv · Apr 8, 2021Pharmacology & Toxicology
A. Chapp, M. Huber, A. R. Collins, K. Driscoll, J. Behnke, R. Larson, Z. Shan, L. Zhang, Q. Chen
This study shows ethanol metabolism in the CeA to acetate activates NMDAR, causing sympathoexcitation in rats.
bioRxiv · Jul 20, 2020 · PreprintPhysiology
Z. Zhang, Z. Shan, R. Chen, X. Peng, B. Xu, L. Xiao, G. Zhang
This study identifies circ_0005962 as an oncogene in NSCLC that promotes progression via the circ_0005962/miR-382-5p/PDK4 regulatory network.
bioRxiv · Mar 6, 2020 · PreprintCell Biology