Author

A. J. Apostolos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 5 Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. M. Pires· 3 shared M. Pires· 3 shared B. E. Dalesandro· 2 shared M. S. Siegrist· 2 shared C. D. Ellermeier· 1 shared C. Santamaria· 1 shared D. L. Popham· 1 shared D. S. Weiss· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

M. M. Pires

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile

K. W. Bollinger, U. Muh, K. L. Ocius, A. J. Apostolos, M. M. Pires, R. F. Helm, D. L. Popham, D. S. Weiss, C. D. Ellermeier

This study identifies a new family of LDTs in C. difficile that catalyze 3-3 peptidoglycan crosslinking, essential for viability and distinct from previously known YkuD domain LDTs.

bioRxiv · Mar 14, 2024 · PreprintMicrobiology

Structure Activity Relationship of the Stem Peptide in Sortase A mediated Ligation from Staphylococcus aureus

A. J. Apostolos, J. J. Kelly, G. G. Ongwae, M. Pires

The paper evaluates synthetic stem peptide analogs to assess their impact on sortase A activity in S. aureus, showing broad tolerability of substrate variations.

bioRxiv · May 17, 2022Microbiology

Compartment-Specific Measurement of Small Molecule Accumulation into Diderm Bacteria

G. M. Ongwae, I. Lepori, M. D. Chordia, B. E. Dalesandro, A. J. Apostolos, M. S. Siegrist, M. M. Pires

The paper develops BaCAPA, a method to measure small molecule accumulation in specific bacterial compartments, showing its utility for both model and pathogenic bacteria.

bioRxiv · May 5, 2022 · PreprintMicrobiology

Metabolic Processing of Selenium-based Bioisostere of meso-diaminopimelic Acid in Live Bacteria

A. J. Apostolos, T. M. Koyasseril-Yehiya, C. Santamaria, J. R. A. Silva, J. Lameira, M. C. Alves, M. S. Siegrist, M. M. Pires

The paper synthesizes and demonstrates the metabolic processing of a selenium-based bioisostere of m-DAP in live bacteria, showing its incorporation into the peptidoglycan layer.

bioRxiv · Dec 18, 2021Microbiology

SaccuFlow: High-throughput Analysis Platform to Investigate Bacterial Cell Wall Interactions

A. J. Apostolos, N. J. Ferraro, B. E. Dalesandro, M. Pires

SaccuFlow is a high-throughput flow cytometry assay that evaluates bacterial peptidoglycan interactions, demonstrating compatibility with Gram-positive, Gram-negative, and mycobacterial sacculi.

bioRxiv · Apr 14, 2021Microbiology

Facile Synthesis and Metabolic Incorporation of m-DAP Bioisosteres Into Cell Walls of Live Bacteria

A. J. Apostolos, J. Nelson, M. Pires

This study develops a synthetic method to create m-DAP bioisosteres for bacterial cell wall probes, demonstrating their metabolic incorporation in live bacteria.

bioRxiv · Apr 3, 2020Microbiology