Author

A. J. Firestone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Inguva· 1 shared A. Long· 1 shared A. R. Howell· 1 shared B. F. Cravatt· 1 shared B. Huang· 1 shared C. H. Jan· 1 shared C. L. Henry· 1 shared F. E. McAllister· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Inguva

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2 papers

Recent·Most cited

ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth

J. R. Remsberg, R. M. Suciu, N. A. Zambetti, T. W. Hanigan, A. J. Firestone, A. Inguva, A. Long, N. Ngo, K. M. Lum, C. L. Henry, S. K. Richardson, M. Predovic, B. Huang, A. R. Howell, M. J. Niphakis, , B. F. Cravatt

This study identifies ABD957, a selective ABHD17 inhibitor, which disrupts N-Ras depalmitoylation and inhibits NRAS-mutant AML growth, suggesting potential as a targeted therapy.

bioRxiv · May 21, 2020Cancer Biology

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

M. F. Pech, L. E. Fong, J. E. Villalta, L. J. G. Chan, S. Kharbanda, J. J. O'Brien, F. E. McAllister, A. J. Firestone, C. H. Jan, J. Settleman

The paper identifies DCAF15 as a target for enhancing NK cell-mediated cancer cell clearance through CRISPR screens and functional analysis in leukemia cells.

bioRxiv · Jul 20, 2019Cancer Biology