Author

J. E. Villalta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. H. Jan· 2 shared A. J. Firestone· 1 shared B. D. Bennett· 1 shared F. E. McAllister· 1 shared F. McAllister· 1 shared J. J. O'Brien· 1 shared J. R. Lazzari-Dean· 1 shared J. Settleman· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

C. H. Jan

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Author profile →

2 papers

Recent·Most cited

Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption

J. Yong, J. E. Villalta, N. Vu, M. A. Kukurugya, N. Olsson, M. P. Lopez, J. R. Lazzari-Dean, K. Hake, F. McAllister, B. D. Bennett, C. H. Jan

The paper identifies lipid homeostasis as a regulator of proteostasis, showing that lipid dysregulation disrupts ESCRT function and causes lysosomal protein aggregation.

bioRxiv · Nov 23, 2022 · PreprintCell Biology

Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance

M. F. Pech, L. E. Fong, J. E. Villalta, L. J. G. Chan, S. Kharbanda, J. J. O'Brien, F. E. McAllister, A. J. Firestone, C. H. Jan, J. Settleman

The paper identifies DCAF15 as a target for enhancing NK cell-mediated cancer cell clearance through CRISPR screens and functional analysis in leukemia cells.

bioRxiv · Jul 20, 2019Cancer Biology