Author

M. J. Niphakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

B. F. Cravatt· 2 shared C. L. Henry· 2 shared K. M. Lum· 2 shared N. Ngo· 2 shared R. M. Suciu· 2 shared A. Gurkan Ozer· 1 shared A. Inguva· 1 shared A. J. Firestone· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersAnimal Behavior & Cognition

B. F. Cravatt

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Author profile →

4 papers

Recent·Most cited

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

S. Yan, A. Santoro, M. J. Niphakis, A. M. Pinto, C. L. Jacobs, R. Ahmad, R. M. Suciu, B. R. Fonslow, R. B. Herbst-Graham, N. Ngo, C. L. Henry, D. M. Herbst, A. Saghatelian, B. B. Kahn, E. D. Rosen

This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.

bioRxiv · Aug 8, 2023 · PreprintPhysiology

Stimulatory effect of monoacylglycerol lipase inhibitor MJN110 on locomotion and step kinematics demonstrated by high-precision 3D motion capture in mice

B. M. Ignatowska-Jankowska, A. Gurkan Ozer, A. Kuck, M. J. Niphakis, D. Ogasawara, B. F. Cravatt, M. Y. Uusisaari

This study shows that inhibiting monoacylglycerol lipase (MJN110) enhances locomotion and step kinematics in mice, while inhibiting fatty acid amide hydrolase (PF3845) suppresses it, revealing distinct effects of endocannabinoid pathway manipulations on motor behavior.

bioRxiv · Jun 25, 2023 · PreprintAnimal Behavior & Cognition

Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host

O. Onguka, B. M. Babin, M. Lakemeyer, I. T. Foe, N. Amara, S. M. Terrell, K. M. Lum, P. Cieplak, M. J. Niphakis, J. Z. Long, M. Bogyo

This study identifies serine hydrolases in Toxoplasma gondii that hydrolyze lipid esters, showing their role in lipid metabolism and potential as therapeutic targets.

bioRxiv · Nov 24, 2020Microbiology

ABHD17 enzymes regulate dynamic plasma membrane palmitoylation and N-Ras-dependent cancer growth

J. R. Remsberg, R. M. Suciu, N. A. Zambetti, T. W. Hanigan, A. J. Firestone, A. Inguva, A. Long, N. Ngo, K. M. Lum, C. L. Henry, S. K. Richardson, M. Predovic, B. Huang, A. R. Howell, M. J. Niphakis, , B. F. Cravatt

This study identifies ABD957, a selective ABHD17 inhibitor, which disrupts N-Ras depalmitoylation and inhibits NRAS-mutant AML growth, suggesting potential as a targeted therapy.

bioRxiv · May 21, 2020Cancer Biology