W. H. Roos

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility

This study investigates how glycan-induced structural activation of the HPV capsid facilitates entry by reducing intercapsomere flexibility.

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix

This study shows that cofilin-1 phosphorylation drives nuclear deformation and enhances dendritic cell migration through extracellular matrix.

A new antibiotic from an uncultured bacterium binds to an immutable target

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

Lateral membrane organization as target of an antimicrobial peptidomimetic compound

This study identifies how the antimicrobial peptide AMC-109 disrupts Staphylococcus aureus membrane organization, leading to loss of methicillin resistance.

Histone chaperones exhibit conserved functionality in nucleosome remodeling

This study uses single-molecule techniques to show that histone chaperones, despite structural differences, have conserved mechanisms in nucleosome remodeling.

Human ESCRT-III Polymers Assemble on Positively Curved Membranes and Induce Helical Membrane Tube Formation

This study investigates how ESCRT-III proteins assemble on curved membranes and induce helical tube formation using in vitro experiments and imaging techniques.

Synaptotagmin-1 and Doc2b exhibit distinct membrane remodeling mechanisms

This study compares how Synaptotagmin-1 and Doc2b remodel membranes through different mechanisms, revealing distinct roles in Ca2+-triggered secretion.

Real-time assembly of an artificial virus elucidated at the single-particle level

This study uses single-molecule techniques to track real-time assembly of artificial virus-like particles, revealing nucleation and DNA packaging mechanisms.

One-dimensional sliding assists σ70-dependent promoter binding by Escherichia coli RNA polymerase

This study uses single-molecule imaging to show Escherichia coli RNA polymerase σ70 holoenzyme performs one-dimensional sliding on DNA during promoter search, even at high RNAP concentrations.