Author

A. J. MacNeil

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. J. Watson· 2 shared K. C. Whitley· 2 shared R. E. MacPherson· 2 shared A. A. Marais· 1 shared A. M. Richard· 1 shared B. D. Roy· 1 shared B. Hockey· 1 shared B. J. Baranowski· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

C. J. Watson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Antibody targeting of aging damaged isoDGR-protein doubles lifespan in a mouse model of chronic inflammation

P. Kalailingam, K.-H. Mohd-Kahliab, S. C. Ngan, R. Iyappan, E. Melekh, T. Lu, G. W. Zien, B. Sharma, T. Guo, A. J. MacNeil, R. E. K. Macpherson, E. L. Tsiani, D. D. O'Leary, K. L. Lim, I. H. Su, , S. K. Sze

This paper shows that targeting aging-damaged isoDGR-proteins with antibodies extends lifespan in a mouse model of chronic inflammation.

bioRxiv · Mar 11, 2023 · PreprintBiochemistry

GSK3 inhibition improves skeletal muscle function and whole-body metabolism in the severe DBA/2J mdx mouse model

B. M. Marcella, B. Hockey, J. L. Braun, K. C. Whitley, M. S. Geromella, R. W. Baranowski, C. J. Watson, S. Silvera, S. I. Hamstra, L. J. Wasilewicz, R. W. Crozier, A. A. Marais, R. Vandenboom, B. D. Roy, A. J. MacNeil, , V. Fajardo

This study shows that GSK3 inhibition improves skeletal muscle function and insulin sensitivity in mdx mice, either alone or combined with exercise.

bioRxiv · Feb 16, 2022 · PreprintPhysiology

Kynurenine metabolism is altered in mdx mice: a potential muscle to brain connection

E. N. Copeland, K. C. Whitley, C. J. Watson, B. J. Baranowski, N. Kurgan, A. J. MacNeil, R. E. MacPherson, V. A. Fajardo, D. J. Allison

This study shows that KYN metabolism is altered in D2 mdx mice, with reduced KYNA and KYNA:KYN ratio and anxiety-like behaviors, suggesting a link between muscle disease and brain metabolism.

bioRxiv · Jan 14, 2022Physiology