Author

A. J. Sachla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:genome assembly· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. D. Helmann· 2 shared A. J. Alfonso· 1 shared J. J. Im· 1 shared K. Y. Rhee· 1 shared M. Pineros· 1 shared V. Soni· 1 shared Y. Luo· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

J. D. Helmann

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2 papers

Recent·Most cited

The Bacillus subtilis yqgC-sodA operon protects magnesium-dependent enzymes by supporting manganese efflux

A. J. Sachla, V. Soni, M. Pineros, Y. Luo, J. J. Im, K. Y. Rhee, J. D. Helmann

This paper shows that deletion of the yqgC-sodA operon in Bacillus subtilis causes Mn sensitivity by reducing Mn efflux and inhibiting Mg-dependent enzymes, distinct from efflux-deficient mutants.

bioRxiv · Feb 14, 2024 · PreprintMicrobiology

A simplified method for CRISPR-Cas9 engineering of Bacillus subtilis

A. J. Sachla, A. J. Alfonso, J. D. Helmann

This paper introduces a simplified CRISPR-Cas9 method for editing Bacillus subtilis by targeting an existing erythromycin resistance cassette, eliminating the need for custom gRNA design and cloning.

bioRxiv · Jun 29, 2021Microbiology