V. Soni

The Bacillus subtilis yqgC-sodA operon protects magnesium-dependent enzymes by supporting manganese efflux

This paper shows that deletion of the yqgC-sodA operon in Bacillus subtilis causes Mn sensitivity by reducing Mn efflux and inhibiting Mg-dependent enzymes, distinct from efflux-deficient mutants.

Mutations in rpoB that confer rifampicin resistance can alter levels of peptidoglycan precursors and affect β-lactam susceptibility

This paper studies how rpoB mutations in Bacillus subtilis confer rifampicin resistance and affect β-lactam susceptibility through changes in peptidoglycan precursor levels.

Site level factors that affect the rate of adaptive evolution in humans and chimpanzees; the effect of contracting population size.

The paper investigates adaptive evolution rates in humans and chimpanzees, finding higher rates at more exposed amino acids and lower rates for dissimilar pairs, but with a shallower slope due to population contraction.

Factors that affect the rates of adaptive and non-adaptive evolution at the gene level in humans and chimpanzees

The paper examines factors affecting adaptive and non-adaptive evolution rates in human and chimpanzee genes, finding significant correlations with recombination, protein length, expression level, and gene age.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy

This study maps chemical-genetic interactions in Mycobacterium tuberculosis to identify how carbon metabolism and cell wall structure affect drug efficacy, revealing environment-dependent and -independent interactions.

A new test suggests that balancing selection maintains hundreds of non-synonymous polymorphisms in the human genome

The paper introduces a new test to detect balancing selection in the human genome and finds over a thousand non-synonymous polymorphisms are maintained by it.