Author

A. J. Warren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

K. C. Dent· 2 shared S. Pellegrino· 2 shared A. Agarwal· 1 shared A. Faille· 1 shared B. D. Bax· 1 shared C. Hilcenko· 1 shared E. Mahenthiralingam· 1 shared F. Raza· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

K. C. Dent

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

VAMP2 regulates phase separation of alpha-synuclein

A. Agarwal, F. Raza, C. Hilcenko, K. Stott, N. Morone, A. J. Warren, J. Lautenschlaeger

This study shows that VAMP2 regulates alpha-synuclein phase separation through electrostatic interactions and lipid membrane binding, influencing its condensation and vesicle formation.

bioRxiv · Jun 16, 2023 · PreprintCell Biology

The chemical landscape of the human ribosome at 1.67 A resolution

A. Faille, K. C. Dent, S. Pellegrino, P. Jaako, A. J. Warren

This study presents a high-resolution cryo-EM structure of the human ribosome, revealing the role of RNA methylation and providing insights into drug targeting.

bioRxiv · Feb 28, 2023 · PreprintBiochemistry

A 2.8A structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase

H. Morgan, M. Lipka-Lloyd, A. J. Warren, N. Hughes, J. Holmes, N. P. Burton, E. Mahenthiralingam, B. D. Bax

This paper reports the 2.8Å X-ray structure of zoliflodacin bound to Staphylococcus aureus DNA gyrase, showing its mechanism of DNA cleavage inhibition and improved antibacterial activity.

bioRxiv · Nov 30, 2022 · PreprintBiophysics

Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 A resolution

S. Pellegrino, K. C. Dent, T. Spikes, A. J. Warren

This study presents a 2.15 Å resolution cryo-EM structure of the human 40S ribosomal subunit, revealing RNA and protein modifications and ion coordination.

bioRxiv · Jan 16, 2022Biochemistry