Author

P. Jaako

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Faille· 2 shared A. J. Warren· 1 shared A. Warren· 1 shared C. C. Wong· 1 shared C. Guibentif· 1 shared C. Hilcenko· 1 shared D. Adams· 1 shared D. Sjovall· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

A. Faille

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The chemical landscape of the human ribosome at 1.67 A resolution

A. Faille, K. C. Dent, S. Pellegrino, P. Jaako, A. J. Warren

This study presents a high-resolution cryo-EM structure of the human ribosome, revealing the role of RNA methylation and providing insights into drug targeting.

bioRxiv · Feb 28, 2023 · PreprintBiochemistry

Defective ribosome assembly impairs leukemia stem cell function in a murine model of acute myeloid leukemia

D. Sjovall, S. Ghosh, J. Hansson, C. Guibentif, P. Jaako

This study shows defective ribosome assembly reduces leukemia stem cell survival in a murine AML model without affecting normal hematopoietic cells.

bioRxiv · Jan 22, 2023Cancer Biology

eIF6 rebinding dynamically couples ribosome maturation and translation

P. Jaako, A. Faille, S. Tan, C. C. Wong, N. Escudero-Urquijo, P. Castro-Hartmann, P. Wright, C. Hilcenko, D. Adams, A. Warren

This study shows eIF6 dynamically couples ribosome maturation and translation by sequestering 60S subunits, and its disruption impairs erythropoiesis in mice.

bioRxiv · Sep 6, 2021Cell Biology