Author
E. Mahenthiralingam
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2020-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 19 mutual co-author links5 papers
Recent·Most cited
A 2.8A structure of zoliflodacin in a DNA-cleavage complex with Staphylococcus aureus DNA gyrase
H. Morgan, M. Lipka-Lloyd, A. J. Warren, N. Hughes, J. Holmes, N. P. Burton, E. Mahenthiralingam, B. D. Bax
This paper reports the 2.8Å X-ray structure of zoliflodacin bound to Staphylococcus aureus DNA gyrase, showing its mechanism of DNA cleavage inhibition and improved antibacterial activity.
bioRxiv · Nov 30, 2022 · PreprintBiophysics
Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin
A. J. Mullins, G. Webster, H. J. Kim, J. Zhao, Y. D. Petrova, C. E. Ramming, M. Jenner, J. A. H. Murray, T. R. Connor, C. Hertweck, G. L. Challis, E. Mahenthiralingam
The paper explores polyyne biosynthetic gene clusters in bacteria, identifies a conserved seven-gene cassette in Pseudomonas, and discovers the metabolite protegencin.
bioRxiv · Mar 5, 2021Microbiology
Discovery and biosynthesis of gladiochelins: unusual lipodepsipeptide siderophores from Burkholderia gladioli
Y. Dashti, I. Nakou, A. Mullins, G. Webster, X. Jian, E. Mahenthiralingam, G. Challis
This study identifies two novel lipodepsipeptide siderophores in Burkholderia gladioli, showing they bind ferric iron and are involved in iron acquisition.
bioRxiv · Jun 16, 2020 · PreprintMicrobiology
Kill and cure: genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles
C. Jones, G. Webster, A. J. Mullins, M. Jenner, M. J. Bull, Y. Dashti, T. Spilker, J. Parkhill, T. R. Connor, J. J. LiPuma, G. L. Challis, E. Mahenthiralingam
This study examines the genomic phylogeny and bioactivity of 206 Burkholderia gladioli strains, identifying toxin-producing clades and potential therapeutic strategies for CF-related infections.
bioRxiv · Apr 9, 2020Microbiology