Author

S. Pellegrino

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

A. J. Warren· 2 shared K. C. Dent· 2 shared A. Achour· 1 shared A. D. Duru· 1 shared A. Faille· 1 shared C. Camilloni· 1 shared C. Madhurantakam· 1 shared C. Paissoni· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

A. J. Warren

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Author profile →

5 papers

Recent·Most cited

The chemical landscape of the human ribosome at 1.67 A resolution

A. Faille, K. C. Dent, S. Pellegrino, P. Jaako, A. J. Warren

This study presents a high-resolution cryo-EM structure of the human ribosome, revealing the role of RNA methylation and providing insights into drug targeting.

bioRxiv · Feb 28, 2023 · PreprintBiochemistry

Multi-eGO: an in-silico lens to look into protein aggregation kinetics at atomic resolution

E. Scalone, L. Broggini, C. Visentin, D. Erba, F. Bacic Toplek, K. Peqini, S. Pellegrino, S. Ricagno, C. Paissoni, C. Camilloni

The paper introduces multi-eGO, a computational model that simulates protein aggregation kinetics at atomic resolution, showing agreement with experimental data on Transthyretin peptides.

bioRxiv · Feb 18, 2022Biochemistry

Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 A resolution

S. Pellegrino, K. C. Dent, T. Spikes, A. J. Warren

This study presents a 2.15 Å resolution cryo-EM structure of the human 40S ribosomal subunit, revealing RNA and protein modifications and ion coordination.

bioRxiv · Jan 16, 2022Biochemistry

Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and -deficient cells

J. Michelena, S. Pellegrino, V. Spegg, M. Altmeyer

The paper shows that 53BP1 recruitment to damaged replicated chromatin is inefficient in both BRCA1-proficient and -deficient cells, revealing a dual switch model in DNA repair pathway choice.

bioRxiv · Feb 24, 2020Cell Biology

Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination

A. Achour, A. D. Duru, R. Sun, E. B. Allerbring, J. Chadderton, N. Kadri, X. Han, H. Uchtenhagen, C. Madhurantakam, S. Pellegrino, T. Sandalova, P.-A. Nygren, S. J. Turner

This paper shows that modifying peptides with proline can restore CD8 T-cell recognition of viral escape variants, enhancing vaccine effectiveness against immune evasion.

bioRxiv · Dec 2, 2019Immunology