Novel inhibitors of E. coli lipoprotein diacylglyceryl transferase are insensitive to resistance caused by lpp deletion
J. Diao, R. Komura, T. Sano, H. Pantua, K. M. Storek, H. Inaba, H. Ogawa, C. L. Noland, Y. Peng, S. L. Gloor, D. Yan, J. Kang, A. K. Katakam, N. N. Nickerson, C. D. Austin, , S. B. Kapadia
The paper identifies Lgt inhibitors that remain effective against E. coli even when lpp is deleted, showing Lgt is a robust antibacterial target.
bioRxiv · Oct 4, 2020 · PreprintMicrobiology