Author

E. Verschueren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:wet-lab / biochemical assay· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. R. Johnson· 4 shared N. J. Krogan· 4 shared B. W. Newton· 3 shared A. Ashworth· 1 shared A. D. Frankel· 1 shared A. Dey· 1 shared A. J. Sabnis· 1 shared A. K. Katakam· 1 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

J. R. Johnson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Chlamydia trachomatis secreted effector CebN targets nucleoporins and Rae1 to antagonize STAT1 nuclear import

B. Steiert, C. A. Elwell, X. Tijerina, M. A. Elliott, Y. Delgado, J. NI, R. Faris, P. Smith, S. E. Andersen, P. N. McCaslin, J. K.-Y. Kevil-Yeager, Q. Eldridge, B. S. Imai, J. V. Arrington, P. M. Yau, , M. M. Weber

This study identifies CebN, a Chlamydia trachomatis effector that targets nucleoporins and Rae1 to disrupt STAT1 nuclear import, aiding bacterial survival.

bioRxiv · Apr 25, 2024 · PreprintMicrobiology

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

T. H. Pham, K. B. Pahuja, T. J. Hagenbeek, J. Zbieg, C. L. Noland, V. C. Pham, X. Yao, C. M. Rose, K. C. Browder, H.-J. Lee, M. Yu, M. Liang-Chu, S. E. Martin, E. Verschueren, J. Li, , A. Dey

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

bioRxiv · Oct 3, 2023 · PreprintCancer Biology

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

T. Maculins, E. Verschueren, T. Hinkle, P. Chang, C. Chalouni, J. Lim, A. K. Katakam, R. C. Kunz, B. K. Erickson, T. Huang, M. Choi, T.-H. Tsai, O. Vitek, M. Reichelt, J. R. Rohde, , A. Murthy

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

bioRxiv · Sep 10, 2020Cell Biology

Fi-score: a novel approach to characterise protein topology and aid in drug discovery studies

A. Kanapeckaite, C. Beaurivage, M. Hancock, E. Verschueren

The paper introduces Fi-score, a method to characterise protein topology using dihedral angles and B-factors to aid in drug discovery by identifying binding sites and structural importance.

bioRxiv · Jun 25, 2020Biophysics

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

J. R. Johnson, T. Parry, T. Repasy, K. M. Geiger, E. Verschueren, J. M. Budzik, D. Jimenez-Morales, B. W. Newton, E. Powell, L. Coscoy, D. A. Portnoy, N. J. Krogan, J. S. Cox

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

bioRxiv · May 27, 2020 · PreprintMicrobiology

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

J. R. Johnson, D. C. Crosby, J. F. Hultquist, D. Li, J. Marlett, J. Swann, R. Hüttenhain, E. Verschueren, T. L. Johnson, B. W. Newton, M. Shales, P. Beltrao, A. D. Frankel, A. Marson, O. I. Fregoso, , N. J. Krogan

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

bioRxiv · Jan 6, 2020Microbiology

Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

N. Chatterjee, E. Pazarentzos, G. Hrustanovic, L. Lin, E. Verschueren, J. R. Johnson, M. Hofree, J. J. Yan, V. Olivas, B. W. Newton, J. V. Dollen, C. H. Earnshaw, J. Flanagan, E. Chan, S. Asthana, , T. G. Bivona

The paper identifies PDHK1 as a synthetic-essential gene in PTEN-deficient cells and cancers, showing its upregulation drives aerobic glycolysis and correlates with poor patient survival.

bioRxiv · Oct 11, 2018Cancer Biology