Z. Modrusan

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

Glomerular immune injury promotes anti-tumor activity

This study shows that glomerular immune injury increases anti-tumor activity by altering bone marrow transcription in mice.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal aging

The paper analyzes aging and senescence in kidney glomeruli using bulk and single-cell RNA sequencing, identifying mesangial cells as key contributors to age-related renal dysfunction.

The renal capsule, a vibrant and adaptive cell environment of the kidney in homeostasis and aging

This study characterizes the renal capsule's cellular composition and dynamics in health, aging, and disease, revealing its adaptive responses and age-related changes.

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity

This study shows that QPCTL inhibition reduces monocyte migration and alters myeloid cell infiltration, enhancing anti-tumor immunity when combined with anti-PD-L1 therapy.

Antigen-derived peptides directly engage the unfolded-protein sensor IRE1α to curb cross-presentation by dendritic cells

The paper shows antigen-derived peptides activate IRE1α in dendritic cells, reducing MHC-I expression and cross-presentation, and demonstrates that IRE1 inhibition enhances anti-tumor immunity.

Surveillance of in situ tumor arrays reveals early environmental control of cancer immunity

This study introduces STAMP, a method to monitor tumor-immune dynamics in vivo, showing immune phenotypes evolve over time and correlate with therapeutic response.

Noncanonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α promotes cancer-cell survival

The paper identifies a noncanonical mRNA decay process, RIDDLE, mediated by IRE1α oligomers in cancer cells, which promotes survival by degrading mRNAs without XBP1-like endomotifs.

G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

This study shows G9a methyltransferase regulates Wnt signaling in lung development and tumor progression by controlling β-catenin transcriptional activity, and its inhibition prevents KrasG12D lung cancer.

Heterogeneity of satellite cells implicates DELTA1/ NOTCH2 signaling in self-renewal

The paper identifies DELTA1/NOTCH2 signaling as critical for satellite cell self-renewal during muscle regeneration by analyzing single-cell RNA sequencing data and using antagonistic antibodies.

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies

The paper uses scBCR-seq to analyze B-cell repertoires and identifies antigen-reactive antibodies with high accuracy.