Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling
P. Singh, S. Agarwal, I. Volpi, L. P. Wilhelm, G. Becchi, A. Keenlyside, T. Macartney, R. Toth, A. Rousseau, G. Masson, I. G. Ganley, M. M. K. Muqit
The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.
bioRxiv · Mar 20, 2023Biochemistry