T. Macartney

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA

The paper identifies 2,204 potential PPP2CA substrates using proteolysis-targeting chimeras and phospho-proteomic analysis, revealing novel substrates and a pSP/pTP motif preference.

Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

The paper identifies novel ATR-dependent phospho-proteomic targets and reveals new biomarkers and genome maintenance factors through screening with ATR inhibitors.

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

Kinome screening identifies integrated stress response kinase EIF2AK1 / HRI as a negative regulator of PINK1 mitophagy signaling

The paper identifies EIF2AK1/HRI as a negative regulator of PINK1 mitophagy signaling through siRNA screening and pharmacological inhibition.

Interaction with C21ORF2 controls the cellular functions of the NEK1 kinase

This study identifies C21ORF2 as a regulatory subunit of NEK1, showing that their interaction is critical for NEK1 function and that mutations disrupt this interaction, linking it to disease.

Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation

The paper identifies UFSP1 as an active protease that matures UFM1 and regulates UFMylation, distinguishing it from UFSP2 in substrate specificity and function.

Mapping of a N-terminal α-helix domain required for human PINK1 stabilisation, Serine228 autophosphorylation and activation in cells

This study identifies an N-terminal α-helix domain in PINK1 critical for its stabilization, autophosphorylation, and activation, linking mutations in this region to Parkinson's disease.

IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling

This study shows IMiDs degrade FAM83F via CK1α interaction, reducing Wnt signaling in colorectal cancer cells.

FAM83F regulates canonical Wnt signalling through an interaction with CK1α

This study identifies FAM83F as a regulator of canonical Wnt signaling through its interaction with CK1α, showing it enhances signaling in Xenopus embryos and human colorectal cancer cells.

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

This study identifies novel SGK3 substrates, including endosomal proteins, through phosphoproteomic screens and shows SGK3 specifically phosphorylates these proteins at sites distinct from Akt.

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

This study identifies PPM1H as a phosphatase that counteracts LRRK2 signaling by dephosphorylating Rab proteins, suggesting it as a potential therapeutic target for Parkinson's disease.

FAM83D directs protein kinase CK1α to the mitotic spindle for proper spindle positioning

This study identifies FAM83D as a scaffold that recruits CK1α to the mitotic spindle, ensuring proper spindle positioning and timely cell division.