Author

A. L. Hughes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 3 Organism:yeast· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. M. English· 4 shared J. M. Shaw· 3 shared T. Xiao· 3 shared V. P. S. Shakya· 2 shared B. Kornmann· 1 shared C. S. Knutson· 1 shared J. A. Maschek· 1 shared J. E. Cox· 1 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCell Biology

A. M. English

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genetic Screen Uncovers a Dual Role for Phospholipids in Mitochondrial-Derived Compartment Biogenesis

T. Xiao, A. M. English, J. A. Maschek, J. E. Cox, A. L. Hughes

The paper identifies distinct roles for cardiolipin and phosphatidylethanolamine in mitochondrial-derived compartment (MDC) biogenesis, showing cardiolipin is required for MDC formation while phosphatidylethanolamine depletion triggers it during amino acid stress.

bioRxiv · Feb 16, 2023 · PreprintCell Biology

Amino Acids Promote Mitochondrial-Derived Compartment Formation in Mammalian Cells

M. H. Schuler, A. M. English, L. Vandermeer, J. M. Shaw, A. L. Hughes

This study identifies mammalian Mitochondrial-Derived Compartments (MDCs) that form in response to amino acid excess and are conserved from yeast.

bioRxiv · Dec 23, 2020 · PreprintCell Biology

ER-Mitochondria Contacts Promote Mitochondrial-Derived Compartment Biogenesis

A. M. English, B. Kornmann, J. M. Shaw, A. L. Hughes

The paper identifies ER-mitochondria contacts as sites for mitochondrial-derived compartment (MDC) biogenesis, showing it requires ERMES and Gem1 GTPase.

Journal of Cell Biology · Oct 22, 2020Peer-reviewedCell Biology

The Nucleus is a Quality Control Center For Non-Imported Mitochondrial Proteins

V. P. S. Shakya, W. A. Barbeau, T. Xiao, C. S. Knutson, A. L. Hughes

The paper identifies the nucleus as a site for disposing of non-imported mitochondrial precursor proteins in yeast through proteasome-based quality control.

bioRxiv · Jun 26, 2020Cell Biology

The GET Pathway Safeguards Against Non-Imported Mitochondrial Protein Stress

T. Xiao, V. P. S. Shakya, A. L. Hughes

The study shows the GET pathway directs non-imported mitochondrial proteins to the ER, preventing toxicity and enabling their re-import via the ER-SURF pathway.

bioRxiv · Jun 26, 2020 · PreprintCell Biology

Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress

M.-H. Schuler, A. M. English, T. J. Campbell, J. M. Shaw, A. L. Hughes

The paper identifies mitochondrial-derived compartments (MDCs) as structures that protect cells from amino acid stress by sequestering Tom70 and coordinating with the MVB pathway.

bioRxiv · Mar 13, 2020Cell Biology