Author

J. M. Shaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. L. Hughes· 3 shared A. M. English· 3 shared A. Frost· 1 shared A. Yusuf· 1 shared B. Kornmann· 1 shared C. L. Tooke· 1 shared C. Reding· 1 shared D. A. Agard· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

A. L. Hughes

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Harvesting and amplifying gene cassettes confers cross-resistance to critically important antibiotics

P. Dulyayangkul, T. Beavis, W. W. Lee, R. Ardagh, F. Edwards, F. Hamilton, I. Head, K. J. Heesom, O. Mounsey, M. Murarik, C. Reding, N. Satapoomin, J. M. Shaw, Y. Takebayashi, C. L. Tooke, , M. B. Avison

The paper shows that gene cassettes in an integron, amplified by IS26, confer resistance to amikacin and piperacillin/tazobactam, often leaving meropenem as the last-resort antibiotic.

bioRxiv · Dec 2, 2023 · PreprintMicrobiology

Amino Acids Promote Mitochondrial-Derived Compartment Formation in Mammalian Cells

M. H. Schuler, A. M. English, L. Vandermeer, J. M. Shaw, A. L. Hughes

This study identifies mammalian Mitochondrial-Derived Compartments (MDCs) that form in response to amino acid excess and are conserved from yeast.

bioRxiv · Dec 23, 2020 · PreprintCell Biology

ER-Mitochondria Contacts Promote Mitochondrial-Derived Compartment Biogenesis

A. M. English, B. Kornmann, J. M. Shaw, A. L. Hughes

The paper identifies ER-mitochondria contacts as sites for mitochondrial-derived compartment (MDC) biogenesis, showing it requires ERMES and Gem1 GTPase.

Journal of Cell Biology · Oct 22, 2020Peer-reviewedCell Biology

Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress

M.-H. Schuler, A. M. English, T. J. Campbell, J. M. Shaw, A. L. Hughes

The paper identifies mitochondrial-derived compartments (MDCs) as structures that protect cells from amino acid stress by sequestering Tom70 and coordinating with the MVB pathway.

bioRxiv · Mar 13, 2020Cell Biology

Structural Basis of Mitochondrial Receptor Binding and GTP Driven Conformational Constriction by Dynamin-Related Protein 1

R. Kalia, R. Y.- R. Wang, A. Yusuf, P. V. Thomas, D. A. Agard, J. M. Shaw, A. Frost

This study presents cryoEM structures of DRP1 bound to MID49 and nucleotides, revealing how GTP binding drives conformational changes essential for mitochondrial fission.

bioRxiv · Aug 7, 2017Biophysics