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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
14 papers
Recent·Most cited
S. Verma, S. D. Giagnocavo, M. C. Curtin, M. Arumugam, S. M. Osburn-Staker, G. Wang, A. Atkinson, D. A. Nix, D. H. Lum, J. E. Cox, K. I. Hilgendorf
This study identifies ZAG/AZGP1 as a secreted factor from triple-negative breast cancer cells that promotes fibrosis in the tumor microenvironment and is linked to poor patient prognosis.
bioRxiv · Mar 4, 2024Cancer Biology
J. L. Shahtout, H. Eshima, P. J. Ferrara, J. A. Maschek, J. E. Cox, M. J. Drummond, K. Funai
This study shows that inhibiting the Lands cycle in skeletal muscle reduces lipid hydroperoxide levels, protecting against disuse-induced atrophy and weakness in mice.
bioRxiv · Jul 25, 2023Physiology
M. Li, R. R. Berton, Q. Qian, J. A. Maschek, B. Chen, E. Barroso, A. Rauckhorst, T. S. Griffith, E. B. Taylor, J. E. Cox, V. P. Badovinac, G. S. Hotamisligil, L.-s. Song, L. Yang
This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.
bioRxiv · Mar 14, 2023 · PreprintPathology
T. Xiao, A. M. English, J. A. Maschek, J. E. Cox, A. L. Hughes
The paper identifies distinct roles for cardiolipin and phosphatidylethanolamine in mitochondrial-derived compartment (MDC) biogenesis, showing cardiolipin is required for MDC formation while phosphatidylethanolamine depletion triggers it during amino acid stress.
bioRxiv · Feb 16, 2023 · PreprintCell Biology
P. J. Ferrara, M. J. Lang, J. M. Johnson, S. Watanabe, K. L. McLaughlin, J. A. Maschek, A. R. Verkerke, P. Siripoksup, A. Chaix, J. E. Cox, K. H. Fisher-Wellman, K. Funai
This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.
bioRxiv · Dec 21, 2022 · PreprintPhysiology
P. Siripoksup, G. Cao, A. A. A. Cluntun, J. A. Maschek, Q. Pearce, M. J. Lang, H. Eshima, P. C. Opurum, Z. S. Mahmassani, E. B. Taylor, J. E. Cox, M. J. Drummond, J. Rutter, K. Funai
This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.
bioRxiv · Nov 1, 2022 · PreprintPhysiology
J. M. Johnson, A. D. Peterlin, E. Balderas, E. G. Sustarsic, J. A. Maschek, M. J. Lang, A. Jara-Ramos, V. Panic, J. T. Morgan, C. J. Villanueva, A. Sanchez, J. Rutter, I. J. Lodhi, J. E. Cox, K. H. Fisher-Wellman, , K. Funai
This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.
bioRxiv · Aug 26, 2022 · PreprintBiochemistry
H. Eshima, J. L. Shahtout, P. Siripoksup, M. J. Pearson, Z. S. Mahmassani, P. J. Ferrara, A. W. Lyons, J. A. Maschek, A. D. Peterlin, A. R. P. Verkerke, J. M. Johnson, A. Salcedo, J. J. Petrocelli, E. R. Miranda, E. J. Anderson, , K. Funai
This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.
bioRxiv · Dec 17, 2021Physiology
K. G. Hicks, A. A. Cluntun, H. L. Schubert, S. R. Hackett, J. A. Berg, P. G. Leonard, M. A. Ajalla Aleixo, A. Blevins, P. Barta, S. Tilley, S. Fogarty, J. M. Winter, H.-C. Ahn, K. N. Allen, S. Block, , J. Rutter
The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.
bioRxiv · Aug 28, 2021 · PreprintBiochemistry
E. Nuebel, J. T. Morgan, S. Fogarty, J. M. Winter, S. Lettlova, J. A. Berg, Y.-C. Chen, C. U. Kidwell, J. A. Maschek, K. J. Clowers, C. Argyriou, L. Chen, I. Wittig, J. E. Cox, M. Roh-Johnson, , J. Rutter
The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.
bioRxiv · Sep 19, 2020 · PreprintCell Biology
J. A. Berg, Y. Zhou, Y. Ouyang, T. C. Waller, A. A. Cluntun, M. E. Conway, S. M. Nowinski, T. Van Ry, I. George, J. E. Cox, B. Wang, J. Rutter
The paper introduces Metaboverse, a tool for network-aware reaction pattern recognition in metabolic data, identifying regulatory signatures of mitochondrial dysfunction in lung adenocarcinoma and respiratory deficiency models.
bioRxiv · Jun 25, 2020 · PreprintBiochemistry
D. Cortes-Selva, L. Gibbs, J. A. Maschek, T. Van Ry, B. Rajwa, J. E. Cox, E. Amiel, K. C. Fairfax
This study shows that Schistosoma mansoni infection reprograms myeloid cell metabolism in male mice, with sex-dependent effects on cholesterol and glucose metabolism.
bioRxiv · Apr 20, 2020 · PreprintImmunology
P. J. Ferrara, X. Rong, J. A. Maschek, A. R. Verkerke, P. Siripoksup, H. Song, K. C. Krishnan, J. M. Johnson, J. Turk, J. A. Houmard, A. J. Lusis, J. E. Cox, S. R. Shaikh, P. Tontonoz, K. Funai
The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.
bioRxiv · Dec 23, 2019 · PreprintPhysiology
T. D. Heden, J. M. Johnson, P. J. Ferrara, H. Eshima, A. R. Verkerke, E. J. Wentzler, P. Siripoksup, T. M. Narowski, C. B. Coleman, C.-T. Lin, T. E. Ryan, P. T. Reidy, L. E. de Castro Bras, C. M. Karner, C. F. Burant, , K. Funai
The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.
bioRxiv · Apr 9, 2019Physiology