Author

A. L. Shaw

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

J. E. Burke· 3 shared M. A. Parson· 3 shared M. L. Jenkins· 3 shared C. K. Yip· 2 shared N. J. Harris· 2 shared S. Suresh· 2 shared A. A. Prats· 1 shared J. G. Pemberton· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

J. E. Burke

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Molecular basis for plasma membrane recruitment of PI4KA by EFR3

S. Suresh, A. L. Shaw, J. G. Pemberton, M. K. Scott, N. J. Harris, M. A. Parson, M. L. Jenkins, P. Rohilla, A. A. Prats, T. Balla, C. K. Yip, J. E. Burke

The paper reports a cryo-EM structure of EFR3A bound to the PI4KA complex, revealing the molecular mechanism of PI4KA membrane recruitment and its regulation in human disease.

bioRxiv · Apr 30, 2024 · PreprintBiochemistry

Structure of Calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A

A. L. Shaw, S. Suresh, M. A. Parson, N. J. Harris, M. L. Jenkins, C. K. Yip, J. E. Burke

The paper reports a cryo-EM structure of Calcineurin bound to PI4KA, revealing direct interactions with both PI4KA and FAM126A and their conserved binding sequences.

bioRxiv · Apr 9, 2024Biochemistry

ATP-competitive and allosteric inhibitors induce differential conformational changes at the auto-inhibitory interface of Akt

A. L. Shaw, M. A. Parson, L. Truebestein, M. L. Jenkins, T. A. Leonard, J. E. Burke

This study investigates how ATP-competitive and allosteric inhibitors induce different conformational changes in Akt's auto-inhibitory interface across various phosphorylation states.

bioRxiv · Jul 14, 2022 · PreprintBiochemistry