Author

L. Truebestein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

T. A. Leonard· 3 shared A.-C. Gavin· 2 shared C. Gehin· 2 shared J. E. Burke· 2 shared A. L. Shaw· 1 shared A. Sponga· 1 shared B. C. Morriswood· 1 shared D. I. Svergun· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

T. A. Leonard

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Author profile →

4 papers

Recent·Most cited

ATP-competitive and allosteric inhibitors induce differential conformational changes at the auto-inhibitory interface of Akt

A. L. Shaw, M. A. Parson, L. Truebestein, M. L. Jenkins, T. A. Leonard, J. E. Burke

This study investigates how ATP-competitive and allosteric inhibitors induce different conformational changes in Akt's auto-inhibitory interface across various phosphorylation states.

bioRxiv · Jul 14, 2022 · PreprintBiochemistry

Structure and regulation of the Myotonic dystrophy kinase-Related Cdc42-binding Kinase

L. Truebestein, E. Waltenberger, C. Gehin, A.-C. Gavin, T. A. Leonard

The paper presents the structure and membrane-binding properties of C. elegans MRCK1, revealing its homodimeric conformation and interactions with phosphoinositides and Cdc42.

bioRxiv · Mar 11, 2022Biochemistry

In vitro reconstitution of Sgk3 activation by phosphatidylinositol-3-phosphate

D. Pokorny, L. Truebestein, K. D. Fleming, J. E. Burke, T. A. Leonard

This study shows that Sgk3 is activated by PI3P through conformational changes and reconstitutes this activation in vitro using Vps34-mediated PI3P synthesis on liposomes.

bioRxiv · Apr 13, 2021Biochemistry

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

S. Sajko, I. Grishkovskaya, J. Kostan, M. Graewert, K. Setiawan, L. Truebestein, K. Niedermuller, C. Gehin, A. Sponga, M. Puchinger, A.-C. Gavin, T. Leonard, D. I. Svergun, T. K. Smith, B. C. Morriswood, K. Djinovic-Carugo

This study investigates MORN repeat proteins, revealing they are protein-protein interaction modules rather than lipid-binding modules, based on structural and functional analyses of TbMORN1 and homologs.

bioRxiv · Jun 23, 2020Biochemistry