A. M. Harris

Sensitizing solid tumors to CAR-mediated cytotoxicity using synthetic antigens

This study develops synthetic antigens to enhance CAR T cell efficacy against solid tumors by reducing off-target effects and improving tumor targeting.

Activity-based urinary biomarkers of response and resistance to checkpoint blockade immunotherapy

This paper develops INSIGHT, a mass-barcoded peptide sensor for noninvasive monitoring of checkpoint blockade therapy response and resistance in mice.

Remote control of CAR T cell therapies by thermal targeting

This paper develops a thermal targeting platform to remotely control CAR T cell therapies, showing significant enhancement in anti-tumor activity and survival in mouse models.

A likelihood approach for uncovering selective sweep signatures from haplotype data

This paper introduces a likelihood ratio test statistic to detect selective sweep signatures in haplotype data across human and Drosophila populations, identifying known candidate genes.

Identifying and classifying shared selective sweeps from multilocus data

The paper identifies and classifies shared selective sweeps across populations using a new statistic, SS-H12, and finds both known and novel sweep candidates in human genomes.

Detection and classification of hard and soft sweeps from unphased genotypes by multilocus genotype identity

The paper develops methods to detect and classify hard and soft selective sweeps using unphased genotypes, finding they are effective for recent sweeps and population expansions.