Author

J. R. Bowen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:proteomics· 4 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

B. Pulendran· 3 shared M. S. Suthar· 3 shared C. E. McDonald· 2 shared M. G. Zimmerman· 2 shared A. M. Harris· 1 shared A. Sivakumar· 1 shared C. Li· 1 shared C. Montagna· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. Pulendran

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of CHK2 dependent DNA damage response suppresses Zika virus infection through a STING dependent mechanism

H. Ma, C. Li, Y. Wang, E. V. Valore, M. Trisal, H. Sai-yin Hui, P. Hakimpour, J. R. Bowen, T. W. Mak, M. S. Suthar, B. Pulendran

This study shows that inhibiting CHK2 reduces ZIKV production and rescues developmental defects by enhancing STING-dependent antiviral responses.

bioRxiv · Oct 3, 2022 · PreprintImmunology

Activity-based urinary biomarkers of response and resistance to checkpoint blockade immunotherapy

Q. D. Mac, C. Xu, J. R. Bowen, A. Sivakumar, H. Phuengkham, F.-Y. Su, S. Z. Stentz, H. Sim, A. M. Harris, T. T. Li, P. Qiu, G. A. Kwong

This paper develops INSIGHT, a mass-barcoded peptide sensor for noninvasive monitoring of checkpoint blockade therapy response and resistance in mice.

bioRxiv · Dec 10, 2020 · PreprintBioengineering

STAT5: A Target of Antagonism by Neurotropic Flaviviruses

M. G. Zimmerman, J. R. Bowen, C. E. McDonald, E. Young, R. S. Baric, B. Pulendran, M. S. Suthar

The paper identifies STAT5 as a target of antagonism by WNV and ZIKV in human DCs, showing differential inhibition of Jak kinases compared to other flaviviruses.

bioRxiv · Apr 12, 2019Microbiology

West Nile Virus Subverts T Cell Stimulatory Capacity of Human Dendritic Cells

M. G. Zimmerman, J. R. Bowen, C. E. McDonald, B. Pulendran, M. S. Suthar

This study shows West Nile virus infects human dendritic cells, activates antiviral responses, but suppresses T cell activation and cytokine production, impairing T cell immunity.

bioRxiv · Apr 9, 2019 · PreprintMicrobiology

Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells

L. Devlin, G. Perkins, J. R. Bowen, C. Montagna, E. T. Spiliotis

The paper identifies isoform-specific interactions of SEPT9 in breast cancer cells through proteomic analysis, revealing distinct molecular networks and functions for different SEPT9 variants.

bioRxiv · Mar 5, 2019Cell Biology