Author

A. M. Lambowitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Yao· 2 shared R. M. Nottingham· 2 shared A. M. Lentzsch· 1 shared A. Roy· 1 shared B. Song· 1 shared B. T. Jones· 1 shared D. R. Tomchick· 1 shared G. Deschamps-Francoeur· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

J. Yao

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Author profile →

4 papers

Recent·Most cited

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

Y. Hu, V. A. Lopez, H. Xu, J. P. Pfister, B. Song, K. A. Servage, M. Sakurai, B. T. Jones, J. T. Mendell, T. Wang, J. Wu, A. M. Lambowitz, D. R. Tomchick, K. Pawlowski, V. S. Tagliabracci

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

bioRxiv · Apr 24, 2024Biochemistry

High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival

L. Faucher-Giguere, A. Roy, G. Deschamps-Francoeur, S. Couture, R. M. Nottingham, A. M. Lambowitz, M. S. Scott, S. Abou Elela

This study identifies H/ACA snoRNAs in high-grade ovarian cancer that promote cell proliferation and survival by inhibiting apoptosis and enhancing invasion.

bioRxiv · Aug 24, 2021Cancer Biology

Structural basis for template switching by a group II intron-encoded non-LTR-retroelement reverse transcriptase

A. M. Lentzsch, J. L. Stamos, J. Yao, R. Russell, A. M. Lambowitz

This study determines the structure of a group II intron RT template-switching complex, revealing mechanisms of template switching and non-templated addition, and their implications for RNA-seq and retroelement function.

bioRxiv · May 13, 2021Biochemistry

Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

M. M. Temoche-Diaz, M. J. Shurtleff, R. M. Nottingham, J. Yao, R. P. Fadadu, A. M. Lambowitz, R. Schekman

The paper identifies distinct miRNA sorting mechanisms in cancer cell-derived extracellular vesicles, showing selective and non-selective pathways mediated by Lupus La and miR-122 motifs.

bioRxiv · Apr 17, 2019Biochemistry