D. R. Tomchick

Exploiting Bacterial Effector Proteins to Uncover Evolutionarily Conserved Antiviral Host Machinery

The paper identifies evolutionarily conserved host factors that restrict arbovirus replication by using bacterial effector proteins to rescue viral replication in insect cells.

A domain-swapped CaMKII conformation facilitates linker-mediated allosteric regulation

This study identifies a domain-swapped conformation in CaMKII that enables linker-mediated allosteric regulation, demonstrated through structural, computational, and live-cell analyses.

Molecular Determinants for Differential Activation of the Vibrio parahaemolyticus Bile Acid Receptor

This study identifies molecular determinants for differential activation of the Vibrio parahaemolyticus bile acid receptor by showing how specific bile acids bind to the VtrA/VtrC complex and influence pathogenic gene expression.

Structures of an intact yeast V-ATPase alone and in complex with bacterial effector VopQ

This study reports cryo-EM structures of the intact yeast V-ATPase and its complex with the bacterial effector VopQ, revealing interactions and catalytic conformations.

A Legionella effector kinase is activated by host inositol hexakisphosphate

This study identifies Lpg2603 as an active kinase from Legionella pneumophila that requires host IP6 for activity, revealing a unique regulatory mechanism.

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

This study determines high-resolution cryo-EM structures of E. coli hemolysin ClyA oligomers, revealing new oligomeric states and mechanistic insights into pore assembly.