K. Pawlowski

Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts

The paper identifies six proteins that predict response to immune checkpoint therapy across three melanoma cohorts and correlate with patient survival.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Identifying Ferroptosis Inducers, HDAC, and RTK Inhibitor Sensitivity in Melanoma Subtypes through Unbiased Drug Target Prediction

This paper identifies potential drug targets and predicts treatment efficacy and resistance in melanoma subtypes using proteogenomic data and drug sensitivity analysis.

Histopathology-assisted proteogenomics provides foundations for stratification of melanoma metastases

This study integrates histopathology and proteogenomic data from melanoma metastases to identify subtypes and risk factors, offering a basis for personalized treatment strategies.

Comparative Phylogenomics and Phylotranscriptomics Provide Insights into the Genetic Complexity of Nitrogen Fixing Root Nodule Symbiosis

The paper uses phylogenomic and phylotranscriptomic analyses to study the evolution of nitrogen-fixing root nodule symbiosis across the Nitrogen-Fixing Nodulation Clade, finding no convergence at the amino acid level and highlighting the role of NIN as a master regulator.

Structural insights into regulation of the PEAK3 scaffold by 14-3-3

This paper reports the cryo-EM structure of PEAK3 pseudokinase in complex with 14-3-3, revealing an asymmetric binding mechanism and identifying Protein Kinase D as a regulator.

Gene losses resulting in specialized metabolism in the earliest divergent symbiotic Frankia clade can be linked to its low saprotrophic capabilities

The paper investigates nitrogen export in Frankia cluster-2 strains and identifies gene losses linked to specialized metabolism and reduced saprotrophic capabilities.

The mechanism of RNA capping by SARS-CoV-2

This study reveals how SARS-CoV-2 caps its RNA genome through an unconventional mechanism involving RNAylation and methyltransferase activity, identifying potential antiviral targets.

Structural and mechanistic basis for protein glutamylation by the kinase fold

This study reveals how the kinase fold of SidJ catalyzes protein glutamylation and identifies SdjA as a glutamylase regulating SidE-ligases during Legionella infection.

A Legionella effector kinase is activated by host inositol hexakisphosphate

This study identifies Lpg2603 as an active kinase from Legionella pneumophila that requires host IP6 for activity, revealing a unique regulatory mechanism.

LTK is an ER-resident receptor tyrosine kinase that regulates secretion

This study identifies LTK as an ER-resident receptor tyrosine kinase that regulates ER exit sites and ER-to-Golgi transport through interaction and phosphorylation of Sec12.