A small-molecule oral agonist of the human glucagon-like peptide-1 receptor
D. A. Griffith, D. J. Edmonds, J.-P. Fortin, A. S. Kalgutkar, J. B. Kuzmiski, P. M. Loria, A. R. Saxena, S. W. Bagley, C. Buckeridge, J. M. Curto, D. R. Derksen, J. M. Dias, M. C. Griffor, S. Han, V. M. Jackson, , D. A. Tess
The paper describes an orally bioavailable small molecule agonist of the GLP-1R that lowers blood glucose in humans.
bioRxiv · Sep 29, 2020Pharmacology & Toxicology